Peripheral cyclic β-amino acids balance the stability and edge-protection of β-sandwiches
نویسندگان
چکیده
منابع مشابه
Peptide Analogues Containing β-Amino Acids for the Melanocortin System
The melanocortin system is a complex control center that regulates various physiological pathways, which include skin pigmentation, steroidogenesis, sexual function, sebaceous lipid production, energy and weight homeostasis, and food satiety. [1,2] This system consists of five G-protein coupled receptors (MC1R-MC5R), four known endogenous agonists, and two known endogenous antagonists. [2, 3] T...
متن کاملEndomorphin-1 analogs containing α-methyl-β-amino acids exhibit potent analgesic activity after peripheral administration.
This study describes the design and synthesis of endomorphin-1 analogs containing C-terminal aromatic α-methyl-β-amino acids and an N-terminal native tyrosine or 2,6-dimethyl-tyrosine. We show that, in comparison with the parent peptide, these analogs exhibit improved bioactivity and blood-brain barrier penetration after intravenous administration, and have a lower tendency to induce constipati...
متن کاملHelical folding of α/β-peptides containing β-amino acids with an eight-membered ring constraint.
αβα-Tripeptide that contains a cyclic β-amino acid with an eight-membered ring, a cis-2-aminocyclooct-5-enecarboxylic acid (cis-ACOE) or a cis-2-aminocyclooctanecarboxylic acid (cis-ACOC) displayed an 11/9-helical turn in the crystal state. The related α/β-peptide oligomers were shown to adopt 11/9-helical conformations in solution.
متن کاملKinetic resolution of aromatic β-amino acids by ω-transaminase.
Racemic aromatic β-amino acids have been kinetically resolved into (R)-β-amino acids with high enantiomeric excess (>99%) by a novel ω-TA with ca. 50% conversion.
متن کاملEfficient Enzymatic Routes for the Synthesis of New Eight-membered Cyclic β-Amino Acid and β-Lactam Enantiomers.
Efficient enzymatic resolutions are reported for the preparation of new eight-membered ring-fused enantiomeric β-amino acids [(1R,2S)-9 and (1S,2R)-9] and β-lactams [(1S,8R)-3, (1R,8S)-3 (1S,8R)-4 and (1R,8S)-7], through asymmetric acylation of (±)-4 (E > 100) or enantioselective hydrolysis (E > 200) of the corresponding inactivated (±)-3 or activated (±)-4 β-lactams, catalyzed by PSIM or CAL-B...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Organic & Biomolecular Chemistry
سال: 2018
ISSN: 1477-0520,1477-0539
DOI: 10.1039/c8ob01322e